Season 21

2022

•104 Episodes

Episodes

1. Johnny Knoxville; Olivia Cooke; BLACKPINK

Sep 19, 2022

41 min

Jimmy welcomes guests Johnny Knoxville and Olivia Cooke. Musical performance by BLACKPINK.

2. Kathy Griffin; Chad Kroeger and JT Parr; Madison Cunningham

Sep 20, 2022

41 min

Jimmy welcomes guests Kathy Griffin, and Chad Kroeger and JT Parr. Musical performance by Madison Cunningham.

3. John Boyega; Tyler James Williams; Weezer

Sep 21, 2022

42 min

Jimmy welcomes guests John Boyega and Tyler James Williams. Musical performance by Weezer

4. Allison Janney; Chris Estrada; Frankie Quiñones; Yung Gravy

Sep 22, 2022

41 min

Jimmy welcomes guests Allison Janney, Chris Estrada, and Frankie Quiñones. Musical performance by Yung Gravy.

5. Amy Schumer, Charlamagne Tha God, Run the Jewels

Sep 26, 2022

41 min

Jimmy welcomes comic Amy Schumer, TV host Charlamagne Tha God, and a musical performance by Run the Jewels.

6. David Letterman, Tracy Morgan

Sep 27, 2022

41 min

Jimmy welcomes TV host David Letterman and actor Tracy Morgan.

7. Mila Kunis, Ramy Youssef, Future

Sep 28, 2022

41 min

Jimmy welcomes actress Mila Kunis, actor Ramy Youssef, and a musical performance by Future.

8. Ben Stiller, Desus Nice, Yeah Yeah Yeahs

Sep 29, 2022

41 min

Jimmy welcomes producer Ben Stiller, TV personality Desus Nice, and a musical performance by Yeah Yeah Yeahs.

9. Jason Bateman, Action Bronson

Sep 30, 2022

41 min

Jimmy welcomes actor Jason Bateman and a musical performance by Action Bronson.

10. Charlie Hunnam, Iliza Shlesinger, NAV, Don Toliver

Oct 3, 2022

41 min

Charlie Hunnam ("Shantaram"), Iliza Shlesinger ("All Things Aside"), Musical Guests NAV feat. Don Toliver

11. Norman Reedus, Danielle Deadwyler, Miranda Lambert

Oct 4, 2022

41 min

Jimmy welcomes actor Norman Reedus, actress Danielle Deadwyler, and a musical performance by Miranda Lambert.

12. Keanu Reeves, Judd Apatow, Phoenix

Oct 5, 2022

41 min

10.0

Keanu Reeves ("BRZRKR: Vol. 2"), Judd Apatow ("Bros"), Musical Guests Phoenix

13. David Spade, FLO, Mookie Betts

Oct 6, 2022

41 min

Actor David Spade (podcast series, "Fly on the Wall with Dana Carvey and David Spade"); professional baseball player Mookie Betts (documentary "Jackie Robinson: Get to the Bag", Los Angeles Dodgers); Flo performs.

Season 21

Episodes

1. Johnny Knoxville; Olivia Cooke; BLACKPINK

2. Kathy Griffin; Chad Kroeger and JT Parr; Madison Cunningham

3. John Boyega; Tyler James Williams; Weezer

4. Allison Janney; Chris Estrada; Frankie Quiñones; Yung Gravy

5. Amy Schumer, Charlamagne Tha God, Run the Jewels

6. David Letterman, Tracy Morgan

7. Mila Kunis, Ramy Youssef, Future

8. Ben Stiller, Desus Nice, Yeah Yeah Yeahs

9. Jason Bateman, Action Bronson

10. Charlie Hunnam, Iliza Shlesinger, NAV, Don Toliver

11. Norman Reedus, Danielle Deadwyler, Miranda Lambert

12. Keanu Reeves, Judd Apatow, Phoenix

13. David Spade, FLO, Mookie Betts

14. Magic Johnson, Fortune Feimster, Wet Leg

15. Jamie Lee Curtis, Lucas Bravo, Midland, Jon Pardi

16. Jessica Chastain, Maren Morris

17. George Clooney, Julia Roberts, Omar Apollo

18. Josh Gad, Pamela Adlon, Ariel Elias

19. Charlize Theron, Lewis Hamilton, Armani White

20. Lupita Nyong'o, Danai Gurira, Letitia Wright, Duran Duran

21. Quentin Tarantino, Tenoch Huerta, Edgar Winter

22. Gwyneth Paltrow, Patton Oswalt

23. Mindy Kaling, Frank Grillo, Goose

24. Nick Kroll, Yvonne Strahovski, Viagra Boys

25. Rob McElhenney, Emayatzy Corinealdi

26. Dana Carvey, Jonathan Majors

27. Bill Maher, George Conway

28. Jason Momoa, Luke Grimes

29. Brian Tyree Henry, Lizzy Caplan

30. Chris Hemsworth, Meghann Fahy

31. Amy Adams, Maya Rudolph, Jenna Ortega

32. Kumail Nanjiani, Pink

33. Patrick Dempsey, Nicholas Hoult

34. Carey Mulligan, Josh Groban

35. Kristen Bell, David Shrigley

36. Kathryn Hahn, Dominic West

37. Billy Crystal, Kate Berlant

38. David Harbour, Lisa Ann Walter

39. Don Cheadle, Zoey Deutch

40. George Lopez, Haley Lu Richardson

41. Janelle Monáe, Sadie Sink, Rita Wilson

42. Will Ferrell, Colson "Machine Gun Kelly" Baker

43. Jean Smart, Wes Bentley

44. Michelle Obama, Marc Maron

45. Sigourney Weaver, Jovan Adepo

46. Margot Robbie, Jeremy Allen White

47. Brendan Fraser, Diego Calva

48. Seth Rogen, Diego Calva

49. Anna Kendrick, Jermaine Fowler

50. Laura Dern, Jeremy Allen White

51. Joel McHale, Ali Wentworth

52. Austin Butler, Bella Ramsey, Iggy Pop, Peyton Manning, Eli Manning

53. Octavia Spencer, Ramon Rodríguez, Renee Rapp

54. Bryan Cranston

55. Viola Davis, Judd Hirsch

56. Danny DeVito, Lucy DeVito

57. Rob Lowe, Storm Reid, Seal

58. Jennifer Lopez, Chris Perfetti, Fall Out Boy

59. Lily Tomlin, Jane Fonda, Rita Moreno, Sally Field, Jacob Latimore

60. David Duchovny, Zach Shallcross

61. Julia Louis-Dreyfus, Rose Byrne, Bobby Cannavale

62. D'Arcy Carden, Hailey Whitters

63. George Clooney, Snoop Dogg, Coldplay

64. Salma Hayek Pinault, Billy Crudup, Justine Skye

65. Pamela Anderson, Mike Lindell, Fall Out Boy

66. Nick Offerman, Kerry Condon, Sofia Carson, Diane Warren

67. Reese Witherspoon, Wesley Kimmel, "Science Bob" Pflugfelder

68. Cate Blanchett, Patrick Mahomes, Dave Franco

69. Milo Ventimiglia, Charles Barkley, Paramore

70. Orlando Bloom, Lauren Ash, Jordan Davis

71. Katy Perry, Lionel Richie, Mike Epps, Beck

72. Wanda Sykes, RZA, Bailey Zimmerman

73. Keri Russell, Ms. Pat, Logic

74. Anthony Mackie, Chris Distefano, Gracie Abrams

75. Tom Cruise, Camila Morrone

76. Michael B. Jordan, Blake Shelton

77. Courteney Cox, Ike Barinholtz

78. Jon Favreau, Nicole Byer, Tove Lo